Browsing by Author "Kaya, Tijen"
Now showing items 1-18 of 18
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Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception
Karadas, Baris; Kaya, Tijen; Gulturk, Sefa; Parlak, Ahmet; Gursoy, Sinan; Cetin, Ali; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2007)Nimesulide, celecoxib, and DFU (5, 5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone) are nonsteroidal antiinflammatory drugs (NSAIDs) with selective cyclo-oxygenase (COX)-2 blocking properties and ... -
Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis
Koyluogu, Gokhan; Bageivan, Ihsan; Karadas, Baris; Guney, Cengiz; Durmus, Nedim; Altun, Ahmet; Kaya, Tijen (ELSEVIER SCIENCE BV, 2008)The aim of this study was to investigate the effects of peritonitis on spontaneous contractions of ileum and jejunum smooth muscles isolated from rats. Peritonitis was induced by cecal ligation and puncture in 8 rats. ... -
Alterations in spontaneous contractions of rat proximal and distal colon after peritonitis
Yildiz, Turan; Koyluoglu, Gokhan; Bagcivan, Ihsan; Kaya, Tijen; Karadas, Bans; Sarac, Buelent; Cankorkmaz, Levent (W B SAUNDERS CO-ELSEVIER INC, 2007)Background/ Purpose: The aim of this study was to investigate the effect of peritonitis on spontaneous contractions of distal and proximal colon smooth muscle isolated from rats. Methods: Peritonitis was induced by cecal ... -
Changes in spontaneous contractions of rat ileum by aflatoxin in vitro
Gursoy, Nevcihan; Sarac, Bulent; Durmus, Nedim; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen; Bagcivan, Ihsan (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are a group of mycotoxins produced by toxigenic strains of Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius as secondary metabolites. Most of the studies on the aflatoxins have focused mainly ... -
Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi
Bagcivan, Ihsan; Kaya, Tijen; Turan, Mustafa; Karadas, Baris; Sarac, Buelent; Duman, Mustafa (KARGER, 2006)Background/Aims: Nitric oxide (NO) is a major inhibitor in various parts of the gastrointestinal tract. This study was designed to compare the effects of YC-1, NO-independent soluble guanylate cyclase (sGC) activator, and ... -
Do antibiotics contribute to postoperative ileus? Contractile responses of ileum smooth muscle in guinea pigs to long-term parenteral ceftriaxone and ampicillin
Ceran, Canan; Karadas, Baris; Kaya, Tijen; Arpacik, Mehmet; Bagcivan, Ihsan; Sarac, Buelent (BLACKWELL PUBLISHING, 2006)Background: Antibiotics may impair small bowel smooth muscle contractility and contribute to postoperative ileus. The aim of this study was to compare the contractile responses of ileum smooth muscle to different agonists ... -
Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits
Kilicarslan, Hakan; Bagcivan, Ihsan; Yildirim, M. Kemal; Sarac, Bulent; Kaya, Tijen (BLACKWELL PUBLISHING, 2006)Introduction. The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism ... -
Effects and Selectivity of CL 316243, Beta-3-Adrenoceptor Agonist, in Term-Pregnant Rat Myometrium
Kaya, Tijen; Karadas, Baris; Altun, Ahmet; Sarac, Ikram; Bagcivan, Ihsan (KARGER, 2012)Background/Aims: Recent evidence supports a predominant role of beta(3)-adrenoceptors at the end of pregnancy in myometrium. This study was designed to characterize the pharmacology of the selective beta(3)-adrenoceptor ... -
Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro
Sarac, Bulent; Durmus, Nedim; Altun, Ahmet; Turan, Mustafa; Kaya, Tijen; Sencan, Mehmet; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2011)Background/Aims: According to recent studies, the endocannabinoid system plays an important role in both physiological and pathophysiological situations. The purpose of the present study was to investigate the effects of ... -
Effects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancy
Karadas, Baris; Kaya, Tijen; Cetin, Meral; Parlak, Ahmet; Durmus, Nedim; Bagcivan, Ihsan; Gulturk, Sefa (ELSEVIER SCIENCE INC, 2007)Alterations in vascular responses to beta-adrenoceptor agonists in normotensive pregnancy and pre-eclampsia are not fully understood. Thus, we studied changes in vasodilator responses to beta(2)-adrenoceptor agonist ... -
Effects of intravenous anesthetics on the human radial artery used as a coronary artery bypass graft
Gursoy, Sinan; Berkan, Ocal; Bagcivan, Ihsan; Kaya, Tijen; Yildirim, Kemal; Mimaroglu, Caner (W B SAUNDERS CO-ELSEVIER INC, 2007)Objective: Intravenous anesthetics are often used for anesthesia, sedation, and analgesia in the intraoperative and postoperative periods of coronary artery bypass graft (CABG) surgery. This study was designed to investigate ... -
Effects of Proton Pump Inhibitors and H-2 Receptor Antagonists on the Ileum Motility
Kurt, Atilla; Altun, Ahmet; Bagcivan, Ihsan; Koyuncu, Ayhan; Topcu, Omer; Aydin, Cengiz; Kaya, Tijen (HINDAWI PUBLISHING CORPORATION, 2011)Objectives. To investigate the effects of proton pump inhibitors (PPIs) and H-2 receptor antagonists on ileum motility in rats with peritonitis and compare changes with control group rats. Methods. Peritonitis was induced ... -
Evaluation of effects of T and N type calcium channel blockers on the electroencephalogram recordings in Wistar Albino Glaxo/Rij rats, an absence epilepsy model
Durmus, Nedim; Gulturk, Sefa; Kaya, Tijen; Demir, Tuncer; Parlak, Mesut; Altun, Ahmet (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2015)Objectives: It is suggested that excessive calcium entry into neurons is the main triggering event in the initiation of epileptic discharges. We aimed to investigate the role of T and N type calcium channels in absence ... -
Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions
Gursoy, Nevcihan; Durmus, Nedim; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are one of the most potent toxic, mutagenic, teratogenic, cancerogenic, and immunosuppresive substances that naturally Occurring contaminants of food. There are some studies in various animal species that have ... -
Investigation of the relaxant effects of pinacidil and Cromakalim on the sheep sphincter of Oddi
Bagcivan, Ihsan; Kaya, Tijen; Yildirim, M. Kemal; Turan, Mustafa (KARGER, 2006)Background/Aims: ATP-sensitive K+ (KATP) channels play an important role in the regulation of smooth muscle membrane potential. This study was designed to investigate the effects of pinacidil and cromakalim, KATP-sensitive ... -
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft
Berkan, Ocal; Bagcivan, Ihsan; Kaya, Tijen; Yildirim, Kemal; Yildirim, Sahin; Dogan, Kasim (NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS, 2007)The radial artery (RA) is used as a spastic coronary bypass graft. This study was designed to investigate the mechanism of vasorelaxant effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole), a nitric oxide ... -
Nifedipine Enhances the Relaxant Effects of Cyclo-Oxygenase Inhibitors on the Bovine Ciliary Muscle
Toker, Mustafa; Bagcivan, Ihsan; Topalkara, Aysen; Karadas, Baris; Durmus, Nedim; Parlak, Ahmet; Kaya, Tijen (MARY ANN LIEBERT, INC, 2008)Background/Aims: The inhibition of cyclo-oxygenase (COX) enzymes and the blockade of Ca2+ channels play an important role in the regulation of smooth muscle relaxation. This study was designed to investigate the relaxant ... -
Relaxant effects of beta-adrenoceptor agonist formoterol and BRL 37344 on bovine iris sphincter and ciliary muscle
Topalkara, Aysen; Karadas, Baris; Toker, Mustafa I.; Kaya, Tijen; Durmus, Nedim; Turgut, Bulent (ELSEVIER SCIENCE BV, 2006)We investigated the relaxant effect Of beta(2)-adrenoceptor agonist formoterol and beta(3)-adrenoceptor agonist BRL 37344 on bovine iris sphincter and ciliary muscle and measured CAMP and cGMP levels. his sphincter (n = ...